Dr. Francesco Raimondi
CellNetworks Excellenz Cluster
University of Heidelberg
I’m broadly interested in applying structural and integrative bioinformatics approaches to
characterize and combine heterogeneous experimental information, with a special focus on understanding signal transduction mechanisms in health and disease.
I will present the results of an ongoing collaborative project aimed at revealing, through
integrative modelling, the structure and function of LRRK2, a multi-domain protein with dual GTPase and Kinase activities, which represents the main cause of congenital Parkinson Disease. We have recently proposed the first model of the quaternary structure of this key enzyme, which is now illuminating on new potential ways to allosterically modulate its kinase activity.
I also employ multi-scale methods, spanning from 3D structures to biological pathways, to
interpret the functional consequences of protein variations and modifications from large-scale genomics and proteomics datasets. I will show recent applications of these approaches in cancer genomics, discussing their potential as predictive tools for personalized-medicine applications.
Massimo Donatelli: massimo.donatelli[et]univr.it
Daniele Dell'Orco: daniele.dellorco[et]univr.it
Model systems drive biological research by recapitulating body processes and functions from the molecular to whole organism level. The human body is composed of both cellular and non-cellular material organized in a specialized manner. It is difficult to mimic all aspects of human biology with one in-vitro model. 3D cell culture models are a more accurate representation of the natural environment experienced by cells in the living organism as opposed to growing cells on 2D flat surfaces. In particular, organoids are in-vitro derived 3D cell aggregates derived from primary tissue or stem cells that are capable of self-renewal, self-organization and exhibit organ functionality. Organoids are physiologically relevant and amenable to molecular and cell biological analyses, holding great promise in both basic research and translational applications. The workshop is focused on the identification of organoid models of human diseases, as cancer and cystic fibrosis. The history of organoids and their future applications in the biomedical research is also discussed.
Nell'ambito delle attività dell'Istituto sono svolte numerose ricerche su sistemi cellulari in vitro, che prevedono l'utilizzo di sistemi, nanomerici per la veicolazione di farmaci in linee cellulari tumorali. L'approfondimento di sistemi non di sintesi e l'analisi critica della preparazione di vettori liposomiali adatti a veicolare in modo direzionale un farmaco di elezione per il fenotipo tumorale, è di sicura rilevanza per la sanità pubblica.
Scopo e obiettivi.
Il workshop si propone di informare ed aggiornare i partecipanti sulle possibilità applicative dei liposomi nel trasporto e direzionalità dei farmaci antitumorali.
Informazioni e domanda di iscrizione:
Descrizione e obiettivo dell'evento: The conference will focus on the potentialities of microvescicles and circulating nucleid acids as novel, non invasive tools for tumor diagnosis and progression. Microvescicles are major means of cell communication and emerging important drivers of tumor cell behaviour and cancer-immuno interactions. The conference will cover all these aspects as well as the design of therapeutic strategies based on the use of engineered microvescicles. Applications of 3D Models and Organoids will complete the meeting.
The registration and the payment forms are available on line
at the website: www.aicc.website
The deadline is 1 ottobre 2018.