The future of cancer therapy: the genome editing era

8 Giugno 2017–9 Giugno 2017 giorno intero
Magna Graecia University - Campus S. Venuta - Aula Magna C, 1° Level, Building G
Viale Europa
88100 Catanzaro
50-200 €
Stefania Meschini
The future of cancer therapy: the genome editing era @ Magna Graecia University - Campus S. Venuta - Aula Magna C, 1° Level, Building G | Catanzaro | Calabria | Italia


In June 2017, the Italian Association for Cell Cultures (AICC) have  organized focused meeting dedicated to "Genome Editing". During the
meeting several national and international experts in the field will discuss
this interesting technical innovation and its possible applications in basic,
translational research and design of novel anti-cancer therapy. Genome
editing is a technology that induces specific changes in the DNA of a cell or
organism that allows studying their influence in the determination of the
phenotypic characteristics. The meeting aims to transfer to the participants
the know-how on the currently available methods to induce changes in the
DNA of a cell system and how to use them to accurately study the function
of different genes, to understand how they work and their definitive
biological effects. The meeting will also illustrate several cell and animal
models, and will end with a practical demonstration of advanced models for
the study of different human diseases in order to design innovative
therapeutic approaches. With these specific objectives, the meeting has
been approved by Italian Ministry of Health for Continuous Education and
Training in medical, biological, pharmaceutical and technological areas.
Maria Teresa Di Martino



8 June 2017

10.00 Registration

10.30 Introduction: PierosandroTagliaferri, Pierfrancesco Tassone
Greetings from the Chancellor and local authorities
Pre-meeting: “Hot topics in Medical Oncology:
From genomics to molecular therapies of human cancer”
Chairs: Vito Barbieri (Catanzaro, Italy) - Marco Rossi (Catanzaro, Italy)

11.00 PDL1 analysis and beyond in lung cancer immunotherapy
Umberto Malapelle (Naples, Italy)

11.20 New generation of kinase inhibitor in the continuum of care of thyroid and renal-cell cancer
Speaker to be announced

11.40 CDK inhibitors: a new perspectives in breast cancer
Enrico Ricevuto (L’Aquila, Italy)

12.00 Liquid Biopsy in novel cancer treatment scenario
Marta Castiglia (Palermo, Italy)

12.20 Genomics of ovarian cancer in predictive oncology: the PARP inhibitors case
Ettore Capoluongo (Rome, Italy)

12.40 Discussion and closing remarks

13.00 Light lunch*

14.00 Opening ceremony
Greeting from AICC President Katia Scotlandi (Bologna, Italy)
Welcome and Meeting introduction Maria Teresa Di Martino (Catanzaro, Italy)
Session 1: CRISPR-Cas9-based therapeutic strategies against human diseases
Chairs: Stefania Meschini (Rome, Italy) - Carlo Leonetti (Rome, Italy)

14.30 TALEN gene edited cells for Allogeneic Adoptive Immunotherapy: from clean room to off-the-shelf
Roman Galetto (Cellectis SA, France)

14.50 Genome editing of T lymphocytes for cancer immunotherapy
Chiara Bonini (Milan, Italy)

15.10 CRISPR/Cas9 mediated knock-out of RUNX2 in melanoma cells
Maria Teresa Valenti (Verona, Italy)

15.30 CRISPR/Cas9 rescue of gene dosage in patient-specific models of neurodevelopmental
disorders caused by large CNV
Giuseppe Testa (Milan, Italy)

15.50 Functional genomic in cancer research
Simona Lamba (Turin, Italy)

16.10 Coffee Break*

16.30 CRISPR/Cas9 system on zebrafish to generate human disease model
Gianluca Deflorian (Milan, Italy)

16.50 The use of CRISPR/Cas9 knock-out technology in non-mammalian animal models
Thomas Vaccari (Milan, Italy)

17.10 CRISPR Gene Editing: Resources for High-Throughput Screening and Disease Models
Livio Loffarelli (Thermo Scientific, Italy)

17.30 Novel Technologies For Rapid Generation Of Custom Animal Models And Streamlined
Cloning Workflows (NOT for ECM evaluation)
Matthew Wheeler, Kristofer Müssar (Cyagen Biosciences GmbH, Europe)
Close session and concluding remarks

9 June 2017

Session 2: Insights in Genome Editing Technologies
Chairs: Francesca Zazzeroni (L’Aquila, Italy) - Massimo Donadelli (Verona, Italy)

9.00 Construction of sgRNA-Cas9 complexes and identification of single-cell mutations to
determine editing frequency
Franco Martinez (EuroClone, Italy)

9.20 How to improve your CRISPR genome editing experiments
Mirko Vanetti (Integrated DNA Technologies, Italy)

9.40 Rapid and tunable method to temporally control gene editing based on conditional
Cas9 stabilization
Vincenzo Corbo (Verona, Italy)

10.00 CRISPR/Cas9 for the study of the interactions between viral and cellular proteins
Donato Zipeto (Verona, Italy)

10.20 Targeted Genome Editing using CRISPR Technology (NOT for ECM evaluation)
Silvia Di Meglio (Merck Sigma-Aldrich srl, Italy)
Close session and concluding remarks

10.40 Coffee Break*

Session 3: CRISPR-Cas9 perspectives in genome editing
Chairs: Marcello Maggiolini (Cosenza, Italy) - Michele Caraglia (Naples, Italy)

11.00 A non-integrative strategy to streamline the derivation of isogenic iPSC lines through
the Cas9/sgRNAribonucleoproteic complex
Sebastiano Trattaro (Milan, Italy)

11.20 Epigenome deregulation and mining in leukemias
Lucia Altucci (Naples, Italy)

11.40 Genome editing in human repopulating hematopoietic stem cells
Pietro Genovese (Milan, Italy)

12.00 Genome editing and generation of physiologically relevant model of leukemogenesis
Giovanni Morrone (Catanzaro, Italy)

12.20 High efficiency Genome Editing using EnGenCRISPR/Cas9 Ribonucleoprotein Complexes
(NOT for ECM evaluation)
Karl Von Laer (New England Biolabs, Germany)

12.35 Efficient delivery of Cas9 and gRNA for in vitro use of CRISPR/Cas9 technology (NOT for ECM evaluation)
Guillaume Freund (Polyplus Transfection, France)

Close session and concluding remarks

12.50 Light lunch*

Session 4: Young investigators meeting and round table on genome editing
Chairs: Nicola Amodio (Catanzaro, Italy) - Cirino Botta (Catanzaro, Italy)

14.10 - 14.40 Selected oral presentation

14.50 Round table

Award Ceremony

(Max Partecipants: 160 - Deadline: 22 May 2017)

full programme 2017
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