[02-04 dic 2024] – ROME – The intricate regulation of different signaling pathways is essential for embryonic development and adult tissue homeostasis.
The role of these pathways ranges from modulation of proliferation and differentiation, staminality, cell death, genome stability, cell metabolism, inflammation and immunity. These “good” pathways may be altered during the process of cancer development, either by suppression or enhancement of their signalling, and cancers commonly display aberrant activity within several of these pathways. Like everything in life, too much or not enough of a signal may be similarly detrimental.