From Single Gene Analysis to Single Cell Profiling:
A New Era for Genomic Medicine
Molecular profiling of DNA and RNA has provided valuable new insights into the genetic basis of non-malignant and malignant disorders. These advances have important implications for future research as well as clinical practice in areas such as molecular diagnostics, gene/pathway-directed targeted therapy, which in turn could drive drug discovery. It is well known that both inherited and somatic genetic alterations contribute to disease predisposition and progression, but also shape responsiveness to therapy and treatment complications.
Recent technological advances have enabled the analyses of genomic and epigenomic variation in a comprehensive, high-throughput fashion using next generation sequencing (NGS). NGS has radically transformed cancer research, showing that each tumor type typically exhibits distinct constellations of genetic alterations targeting one or more key cellular pathways that regulate cell growth and proliferation, evasion of the immune system, and other aspects of cancer behavior. These genetic and epigenetic events have been identified and may now be used as prognostic markers or for monitoring disease progression and treatment response, as targets for new therapies, and in the seKng of genetic counseling and disease surveillance.
The conference wants to oﬀer the participants the opportunity to match technological solutions and clinical needs in the era of precision medicine. From circulating biomarkers to mutational, transcriptomics and immunomics landscape, this year meeting will describe a panorama of the renewed plaNorms for personalization of therapy.
The meeting President
Maria Teresa Di Martino
Day 1 - October 1st
9:00 Opening ceremony
Greetings from Academic and AICC authorities
Chairs: Pierosandro Tagliaferri, Pierfrancesco Tassone
9:20 Keynote lecture
Inducing phenotypes, discovering them, and instantly solving them
Bruce A. Beutler, Dallas, TX
10:00 Distinguished lecture – Day 1
The BAP1 cancer syndrome: unique mechanisms and clinical characteristics requiring specific medical approaches
Michele Carbone, Honolulu, HI
10:30 – 11:00 Coﬀee Break and poster visit
11:00 – 12:30 SESSION I
Biomarkers for diagnosis, monitoring of progression and therapeutic response
The development of new technology and clinical standards for discovery and use of biomarkers in disease diagnosis, monitoring and response to therapy.
Chairs: Stefania Meschini, Ka8a Scotlandi
11:05 Precision Medicine and non-communicable diseases
Giuseppe Novelli, Rome, IT
11:25 Microenvironment-driven heterogeneity in cancer: morphological views
Claudio Tripodo, Palermo, IT
11:45 PD-L1 and beyond: from PD-L1 detection to the tumor mutation burden
Andrea Ronchi, Naples, IT
12:05 Evolution of liquid biopsy concept in oncology
Umberto Malapelle, Naples, IT
12:25 Selected oral communication n°1
12:35 Selected oral communication n°2
13:50 – 15:20 SESSION II
Single cell profiling: from bench to bedside
Highlights on the use of single-cell genomics to increase our understanding of the tumor microenvironment and identify new therapeutic targets.
Chairs: Chiara Riganti, Carlo Leonetti
13:55 Understanding the molecular mechanisms underlying T lymphocyte diﬀerentiation and plasticity using Single Cell RNA-Seq
Massimiliano Pagani, Milan, IT
14:15 Genomic principles of signal integration in macrophages
Renato Ostuni, Milan, IT
14:35 Single Cell transcriptomics uncovers distinct molecular signatures of therapy-resistant leukemic stem cells
Alice Giustacchini, London, UK
14:55 Selected oral communication n°1
15:05 Selected oral communication n°2
15:20 – 15:50 Coﬀee Break and poster visit
15:50 – 16:15 TECHNICAL SESSION I
Insights in single gene analysis technologies
The section will include innovative technologies for single events identification from diﬀerent biological matrices and diﬀerent human diseases.
Chair: Marco Rossi, Francesco Trapasso
15:55 Bringing precision oncology closer to patients
Federica Berti, Thermofisher Scientific
16:10 Role of polychromatic flow cytometry and cell sorting in the evaluation of minimal residual disease in acute leukemias
Francesco Gervasi, Beckman Coulter32nd
16:25 Title to be announced
Francesco P. Fiorentino, Kitos Biotech/Gilson Italia SRL
16:40 Becton Dickinson Italia
16:55 Discussion and day 1 take-home message
19:00 – 23:00 Social Event
Day 2 - October 2st
9:00 – 10:50 SESSION III
Functional genomics in clinical practice
This section will highlight the role of «precision functional genomics» in phenotypically characterizing genetic variants at scale.
Chairs: Francesca Zazzeroni, Enrico De Smaele
9:05 Genomic instability in multiple myeloma
Daniele Caracciolo, Catanzaro, IT
9:25 Genomic landscape of pancreatic neuroendocrine tumors
Andrea Maﬃcini, Verona, IT
9:45 Analysis of cancer genomic data to achieve be]er patient stratification and personalized molecular profiling
Javier De Las Rivas, Salamanca, ES
10:05 Novel mechanisms of tumor suppression
Giovanni Tonon, Milan, IT
10:25 Selected oral communication n°5
10:35 Selected oral communication n°6
10:50 – 11:20 Coﬀee Break and poster visit
11:20 Distinguished Lecture – Day 2
Title to be announced
Gerry Melino, Rome, IT
11:50 – 12:50 TECHNICAL SESSION II
Insights in single cell profiling technologies
The section will include innovative technologies for high throughput transcriptomics, genomics, proteomics, immunomics, miRNomics analysis and in vivo models for the dissection of tumor microenvironment.
Chairs: Daniele Torella, Carmela De Marco
11:55 Zebrafish model for neuroendocrine tumors: an in vivo pla_orm for personalized therapy
Giovanni Vitale, Milan, IT
12:10 Biology at true resolution with 10X Genomics
Diego Muzzini, Carlo Erba Reagents
12:25 QIAGEN bioinformatics in NGS: from fastq to interpretation, how to analyze somatic and germline mutations and expression profiling
Mita Mancini, Qiagen
12:50 – 13:50 Light lunch and poster visit
13:50 – 16:00 SESSION IV
Functional immunomics in precision medicine
The section will deal with the use of immunomics as a new research tool in system biology of cellular immune responses, and how this can be exploited to ameliorate cancer immunotherapy
Chairs: Marcello Maggiolini, Massimo Donadelli
13:55 Inﬂammosomics in the prediction of response to immunotherapy
Pierpaolo Correale, Reggio Calabria, IT
14:15 Identiﬁcation of antigenic targets for cancer immunotherapy
Luigi Buonaguro, Naples, IT
14:35 Cancer clonal evolution as therapeutic target
Mariangela Russo, Turin, IT
15:55 Closing lecture
Driving the CAR beyond the checkpoints
Francesco Marincola, California, USA
15:35 AWARD CEREMONY
16:00 CLOSING REMARKS
Sabrina Arena, Istituto di Candiolo – IRCCS, Turin (IT)
Federica Berti, Thermofisher Scientific, Monza (IT)
Bruce A. Beutler, UT Southwestern Medical Center, Dallas (TX)
Luigi Buonaguro, IRCSS Fondazione G. Pascale, Naples (IT)
Daniele Caracciolo, Università degli Studi Magna Græcia di Catanzaro, Catanzaro (IT)
Michele Carbone, University of Hawaii Cancer Center, Honolulu (HI)
Pierpaolo Correale, Grande Ospedale Metropolitano, Reggio Calabria (IT)
Javier De Las Rivas, University of Salamanca, Salamanca (ES)
Francesco P. Fiorentino, Kitos Biotech/Gilson Italia SRL
Francesco Gervasi, Beckman Coulter, Palermo (IT)
Alice Giustacchini, University College London, London (UK)
Andrea Mafficini, University of Verona, Verona (IT)
Umberto Malapelle, Università degli Studi di Napoli Federico II, Naples (IT)
Mita Mancini, Qiagen, Berlin (DE)
Francesco Marincola, Refuge Biotechnologies, Menlo Park (CA)
Gerry Melino, Università Tor Vergata, Rome (IT)
Diego Muzzini, Carlo Erba Reagents, Milan (IT)
Renato Ostuni, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan (IT)
Giuseppe Novelli, Università Tor Vergata, Rome (IT)
Massimiliano Pagani, Università degli Studi di Milano, Milan (IT)
Werner Rodriguez, Becton Dickinson Italia
Andrea Ronchi, IRCSS Fondazione G. Pascale, Naples (IT)
Gianluca Rotta, Becton Dickinson Italia
Giovanni Tonon, Università Vita-Salute San Raffaele, Milan (IT)
Claudio Tripodo, Università degli Studi di Palermo, Palermo (IT)
Giovanni Vitale, Università degli Studi di Milano, Milan (IT)
Local organizing committee
AICC/GISM members - Entire duration
Non-members - Entire duration
AICC/GISM members - One-day registration
Non-members - One-day registrationd
On site registration
Undergraduate and PhD Students
The participation to the conference is reserved to AICC and GISM members. Registration fees include:
– Admission to all meeting sessions and exhibition area
– Abstract book
– Attendance certiﬁcate
– Conference kit
– Coﬀee break, light lunch
*Please indicate any food intolerance on the registration form.
Registration fees do not include travel and accommodation costs.
The registration form and payment details are available online at the link: www.aicc.website
Registration without payment is not considered valid.
The maximum number of participants is 160.
Language: the meeting oﬃcial language is English
Slides: slides must be written in English, and should be handed to the slide centre one hour before the beginning of each session. Computer video projection will be available in Power Point format.
Attendance certiﬁcate: a certiﬁcate of attendance will be sent to all participants at the end of the meeting.
Meeting WiFi: UMG ospiti – KEY WPA2: 3333333333 (10 times 3)
User: aicc.umg Password: Aicc.umg19
The Scientiﬁc Committee encourages all participants to submit their work to be considered for oral or poster presentation. All works should be submitted as 350 words abstract indicating the author’s preference for oral versus poster presentation.
Among the participants, n.6 posters will be selected for oral presentation. The Scientiﬁc Committee will select the oral presentations.
Abstract submission opens June 17th, 2019
Abstract submission closes Aug 23th, 2019
Each author can be the Presenting Author of one abstract only. For each accepted abstract, at least one of the authors has to be registered to the conference.
Submitted abstract should focus on the following topics:
- Biomarkers in malignant and non-malignant disease
- Cancer genetics, genomics and epigenetics
- Cancer immunotherapy
- Cell metabolism
- Gene/pathway-directed targeted therapy
- Genetic screening
- Mechanisms of metastatic spreading
- Tumor-associated immune and stromal cells
AICC will award a number of prizes for best oral or poster presentation by authors younger than 35 years of age. Each award is worth 500 euros.
One 500 euro prize will be awarded to the best poster presentation by an author younger than 35 years of age by the Journal of Experimental and Clinical Cancer Research.
All participants will be admitted to a guided tour of Catanzaro old city. This will be followed by a social dinner held in the beautiful San Giovanni Terrace.
|Abstract submission||Early bird payment||Online registration|
23 Aug 2019
29 sept 2019
29 sept 2019
- AICC Scientiﬁc Board
- AICC Secretariat
Michele Caraglia, Università Vanvitelli di Napoli, Naples (IT)
Stefania Meschini, Istituto Superiore di Sanità, Rome (IT)
Board of Directors and Secretary
Massimo Donadelli, Università di Verona, Verona (IT)
Board of Directors and Treasurer
Francesca Zazzeroni, Università degli Studi dell’Aquila, L’Aquila (IT)
Board of Directors
Maria Teresa Di Martino, Università Magna Græcia, Catanzaro (IT)
Chiara Riganti, Università di Torino, Turin (IT)
Enrico De Smaele, Università La Sapienza, Rome (IT)
Katia Scotlandi, IRCCS Istituto Ortopedico Rizzoli, Bologna (IT)
Massimo Donadelli (massimo.donadelli[at]univr.it)
Evelin Pellegrini (evelin.pellegrini[at]guest.iss.it)
Under the patronage of
With the unrestricted grant of AICC supporters
How to reach the meeting venue
From Lamezia Terme International Airport: it takes a 35 minutes-drive to reach Università Magna Graecia from Lamezia Terme International Airport (SUF).
From the airport, take SS280 towards Catanzaro, proceed until the exit for Germaneto, and continue onto Viale Europa till the University Building. Alternatively, take the bus to either Germaneto, Catanzaro or Catanzaro Lido. Several bus services are available from Monday to Saturday: for more details on timetables and fees, visit https://lameziaairport.it/trasporti/. A local public shuttle connects the airport to Lamezia Terme Centrale railway station.
For timetables, visit http://www.lameziamultiservizi.it
From Lamezia Terme Centrale Railway Station: take the train to either Catanzaro or Catanzaro Lido. For timetables, visit www.trenitalia.it
From Catanzaro Railway Station:
-by public transportation: take either one of the buses U1/U2/U3/U4/U5 towards «CAMPUS».
Info on www.amcspa.it
-by car (15 min): take SS280 towards Lamezia Terme, proceed until the exit for Germaneto, and continue on to Viale Europa until the University Building.
From Catanzaro Lido Railway Station:
-by public transportation: take the U1 bus towards «CAMPUS». Info on www.amcspa.it
-by car: take Strada Provinciale 48 towards Catanzaro until the intersection with Viale Europa, proceed on Viale Europa until the University Building.
From Soverato (25 min): take the Ionian highway 106 northwards up to the intersection with Catanzaro Lido, take a turn towards Lamezia Terme and con’nue onto Viale Europa.
From A3 motorway (Salerno-Reggio Calabria): take the exit for Lamezia Terme/Catanzaro, proceed along SS208 towards Catanzaro until the exit for Germaneto and continue onto Viale Europa.