TARGETED PROTEIN DEGRADATION:
from biology to pharmacology
Targeted protein degradation is an emerging therapeutic modality based on the use of
small molecules called degraders with the potential to tackle “undruggable targets” that
have historically been highly challenging to target with conventional small molecules.
Application of targeted protein degradation embraces experimental procedures based on
engineered systems for ligand-induced protein degradation, computational and medical chemists, and rational design of novel therapeutic approaches.
This meeting will attract the interest of both basic and translational researchers, offering the opportunity to dive into the biggest challenges in early discovery and preclinical stages of targeted protein degradation.
Joining a small but multidisciplinary group of academic and pharma discovery scientists with specific expertise in drug development and experimental modeling, the attendances will learn how to identify new targets, discover novel ligands, and move them from early discovery to potential drug candidate. Interaction with speakers is favored to generate discussion, foster collaboration and knowledge exchange in the field of protein degradation.
Looking forward for meeting you, we welcome you in the lively city of Bologna, with its blend of fascinating culture, history, and delicious traditional food.
Caterina Mancarella – AICC CTS Member
Katia Scotlandi – AICC Past President
Michele Caraglia – AICC President
1.00 – 1:30 pm: Registration and light lunch
1:30 – 1:45 pm: Opening and Greetings
– Prof. Giovanni Francesco Nicoletti
Rector, University of Campania Luigi Vanvitelli
– Prof. Ferdinando De Vita
Director, Department of Medicine and Precision – University of Campania Luigi Vanvitelli
– Prof. Michele Caraglia
AICC President, Italian Association of Cell Cultures (AICC)
Department of Medicine and Precision – University of Campania Luigi Vanvitelli
OPENING LECTURE
1.45-2.20 pm: Human organoids to model disease.
Meritxell Huch, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden (Germany)
2.20-2.40 pm: Questions and answers
SESSION I: ORGANOID TECHNOLOGY Chairs
2.40-2.45 pm: Introduction to the session
2.45-3.05 pm: Extensive characterization of human pancreas organoids.
Lorenza Lazzari, University of Milan, Milan (Italy)
3.05-3.25 pm: Nasal epithelial stem cell-based organoids for personalized therapy in cystic fibrosis
Adriana Eramo, ISS, Rome (Italy)
3.25-3.45 pm: Gastruloid development as in vitro model.
Gabriella Minchiotti, CNR Naples (Italy)
3.45-4.05 pm: Questions and answers
4.05-4.15 pm: selected oral communication #1
4.15-4.25 pm: selected oral communication #2
4.25-4.35 pm: selected oral communication #3
4.35-4.55 pm: Questions and answers
4.55-5.30 pm: Coffee break and posters/virtual stands view
5.30-5.45 pm: Closing remarks of day I
SESSION II: ORGANOIDS AS CANCER MODELS
Chairs Enrico De Smaele, Chiara Riganti
9.15-9.25 am: Introduction to the session
9.25-9.45 am: Targeting invasion in colorectal cancer organoids.
Enza Lonardo, CNR Naples (Italy)
9.45-10.05 am: Gastric cancer organoids: a tool to predict therapeutic efficacy and to model gastric cancer development.
Silvia Giordano, University of Turin (Italy)
10.05-10.25 am: Organoid models for lung cancer: translational perspectives.
Carminia Della Corte, University of Campania, Naples (Italy)
10.25-10.45 am: Coffee break and posters/virtual stands view
10.45-11.05 am: Modeling brain cancer with human organoids.
Luca Tiberi, University of Trento (Italy)
11.05-11.25 am: Pancreatic cancer organoids as a new platform to dissect tumor heterogeneity.
Vincenzo Corbo, University of Verona (Italy)
11.25-11.45 am:METTL16 is a novel therapeutic target in leukemia.
Nunzio Del Gaudio, University of Campania, Naples (Italy)
11.45-12.05 pm: Questions and answers
12.05-12.15 pm: Selected oral communication #1
12.15-12.25 pm: Selected oral communication #2
12.25-12.35 pm: Selected oral communication #3
12.35-12.45 pm: Questions and answers
12.45-1.55 pm: Lunch
SESSION III: ORGANOIDS AS MODELS FOR NON-ONCOLOGICAL DISEASES
Chairs
1.55-2.00 pm: Introduction to the session
2.00-2.20 pm: A Perspective on Organoids for Virology Research.
Matteo Porotto, University of Campania, Naples (Italy)
2.20-2.40 pm: Using human brain organoids to model neurodevelopmental
disorders: the case of Fragile X Syndrome.
Silvia Di Angelantonio, University “La Sapienza”, Rome (Italy)
2.40-3.00 pm: Understanding disrupted molecular pathways in neuropsychiatric
diseases using human-derived brain organoids.
Theo Ribierre, University of Geneva (Switzerland)
3.00-3.20 pm: Questions and answers
3.20-3.40 pm: Intestinal Organoids as a Tool for Inflammatory Bowel Disease.
Nathalie Vergnolle, IRSD, Toulouse (France)
3.40-4.00 pm: 2D and 3D stem cell-based models of dystrophic cardiomyopathy.
Maurilio Sampaolesi, University “La Sapienza”, Rome (Italy)
4.00-4.20 pm: Questions and answers
4.20-4.30 pm: Selected oral communication #1
4.30-4.40 pm: Selected oral communication #2
4.40-4.50 pm: Selected oral communication #3
4.50-5.00 pm: technical talk #1
5.00-5.10 pm: technical talk #2
5.10-5.20 pm: technical talk #3
5.20-5.40 pm: Questions and answers
5:40-6:30 pm: Assemblea Soci AICC/Elections new board
8.00 pm: Social Dinner
SESSION IV: CONTROVERSY SESSION AND NEW ADVANCED METHODS FOR
ORGANOID GROWTH
Chairs
10.00-10.05 am: Introduction to the session
10.05-10.25 am: Will Organs-in-a-Dish Ever Replace Animal Models?
Alex Calon, IMIM, Barcelona (Spain)
10.25-10.45 am: Is there a role for PDOs in RCT? How to design the appropriate trial?
The oncologist’s perspective.
Floriana Morgillo, University of Campania, Naples (Italy)
10.45-11.05 am: Coffee break and posters/virtual stands view
11.05-11.25 am: Nanofibers and nanofiber-derived device for organoid development and nanosensing.
Evzen Amler, Charles University of Prague (Czech Republic)
11.25-11.45 am: Questions and answers
12.05-12.15 pm: AICC awards
12.15-12-35 pm: Concluding remarks and future initiative of AICC
Andrea TESTA – Amphista Therapeutics Limited, Cambridge, UK
Caterina MANCARELLA – IRCCS Istituto Ortopedico Rizzoli, Bologna
Chiara BORSARI – University of Milan
Giuseppe Mancuso – Promega
Giulia CARON – University of Turin
Simone LANFREDINI – Sibylla Biotech, Trento
Maria Laura BOLOGNESI – University of Bologna
| Registration Fees | Meeting fee (VAT included) |
|---|---|
| Meeting Registration | 75 euro |
| Membership | 50 euro |
*Please provide a certificate of your status of student/intern to aicc.meeting@gmail.com
To participate to the meeting is required a valid AICC membership.
Membership request form is available at the following link:
https://www.aicc.website/cosaelaicc/sottoscrizioni/
Membership fee is 50 €.
Reason for payment (causale): please, indicate your surname, name, 2024 AICC Membership”
Registration includes:
– Admission to all meeting sessions
– Attendance certificate
– Conference kit
– Coffee break, light lunch
Registration without payment is not considered valid.
PAYMENT
Bank transfer to:
Associazione Italiana di Colture Cellulari
IT97B0538703612000003002045
BPER BANCA S.P.A.
L’Aquila, agenzia 10, Via Campo di Pile, 67100 L’Aquila (AQ)
Reason for payment (causale): please, indicate your surname, name, “TARGETED PROTEIN DEGRADATION: from biology to pharmacology”
Copy of the receipt must be sent to:
aicc.meeting[at]gmail.com
Please note that this is a provisional registration; the registration will be confirmed after completing the payment and sending the receipt of the payment and the students status declaration to: aicc.meeting@gmail.com
The submission of abstracts for oral presentations or posters is encouraged, particularly from early-career researchers.
Registration to the meeting is required to submit an abstract.
Deadline for abstract submission: 18/11/2022
The abstract form is available on the AICC website:
https://www.aicc.website/
To submit your abstract, please send the filled abstract form to: aicc.meeting@gmail.com
Among the submitted abstracts, the AICC Scientific Board will select oral communications (10 minutes).
Participants will be informed of the selection by 22/11/2022
Guidelines for Preparing Posters
1. Presenters are expected to be at their posters and ready to discuss them during the coffee break/posters manned session.
2. Poster Size – poster size is 70 cm wide x 100 cm high. The organizers will supply material to attach the poster onto the panels.
3. Poster Board Assignments – All poster boards will be numbered, please make sure that you place your poster in the correct location.
| Opening meeting registration | Deadline meeting registration |
|---|---|
| 12 March 2024 | 28 May 2024 |
Michele CARAGLIA
University of Campania “L. Vanvitelli”,Naples, Italy PRESIDENT
Francesca ZAZZERONI
University of L’Aquila, L’Aquila, Italy VICE PRESIDENT
Chiara RIGANTI, (Secretary)
University of Turin, Turin, Italy
Enrico DE SMAELE, (Treasurer)
La Sapienza University of Rome, Rome Italy
Massimo DONADELLI,
University of Verona, Verona Italy
Maria Teresa DI MARTINO,
“Magna Graecia” University, Catanzaro, Italy
Andrea MORANDI,
University of Florence, Florence, Italy
Katia SCOTLANDI, (past President)
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Katia SCOTLANDI
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Caterina MANCARELLA
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Daria CAPECE,
University of L’Aquila, L’Aquila
Simone DI FRANCO,
University of Palermo, Palermo
Alessandra FIORE,
University of Verona, Verona
Joanna KOPECKA,
University of Turin, Turin
Caterina MANCARELLA,
IRCCS Istituto Ortopedico Rizzoli, Bologna
Nicla LORITO,
University of Florence, Florence
Silvia ZAPPAVIGNA,
University of Campania “L. Vanvitelli”, Naples
Pasquale ZIZZA,
Regina Elena National Institute
for Cancer Treatment and Research, Rome
Cristina FERRARI
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Alessandra DE FEO
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Evelin PELLEGRINI
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Marianna CARRABOTTA
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Lisa TORACCHIO
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
AICC will award best oral presentation(s) by authors younger than 35 years of age.
AICC will also award best poster/flash presentation(s) by authors younger than 35 years of age
IRCCS Istituto Ortopedico Rizzoli
Bologna
The Italian Ministry of Health through the Executive Programme of Cooperation in the field of Science and Technology between Italy and the
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