Exosomes are extracellular vesicles of variable diameter between 30 and 200 nm, secreted by the cells in biological fluids. These vesicles can carry within or on their surface lipids, membrane and soluble proteins, mRNA, microRNA and transposons, acting as “signal” transporters between cells.
Exosomes can also be characterized by common molecules defined as “exosomal markers” useful for their identification and purification and can be used as “indicators” of the presence or activity of specific cell types or tumor cells. The presence of circulating biomarkers, such as exosomes, can allow the development of non-invasive diagnostic tests, constant monitoring of disease progression and responses associated with the different therapeutic approaches used.
The “Exosome meetings” underline the need, for researchers and clinicians, to understand the growing complexity of cell-cell communication mechanisms mediated by exosomes
and other microvesicles, both physiological and pathological, and to exploit and modify these mechanisms to ensure innovative therapeutic approaches for effective translation from preclinical outcomes to clinical approaches.
This year’s conference focuses in particular on:
1) exosomes, microvescicles and their role in tumorigenesis and
metastasis
2) role of exosomes in immunity, immuno-evasion and tumor
microenvironment
3) potential use and application of exosomes for diagnostic purposes.
4) use of modified exosomes and microvescicles or sintetic nanoparticles
for the delivery of drugs or chemotherapy.
Young investigators are especially invited to participate and take advantage of the dedicated initiatives, including the awards that AICC and Sapienza University will offer for the best posters (flash presentation) and the best oral presentation.
Really hoping you will appreciate the meeting, we look forward to seeing you all!
The meeting President
Enrico De Smaele
2:00 pm: Welcome from the organizers
2:15 pm: OPENING LECTURE “Exosomes and Microvesicles: Integrators of Homeostasis, players in diseases”
Graca Raposo, CNRS/Institut Curie, Paris
Tumour-microenvironment Interactions And Immunology
Chairs: Alessandra Zingoni and Aurelia Rughetti, Sapienza University
3:00 pm “Intercellular communication in the immune response: Transfer of genetic information by EVs during synapsis”
Francisco Sánchez Madrid, Universidad Autónoma de Madrid
3:45 pm “Adipocyte-derived exosomes and immune education”
Antony Ferrante Jr, Columbia University, NY, USA
4:25 pm Technical Talk: “3D, Label-Free, Live Cell Imaging for Cell Morphology and Phenotyping.”
Daniel Ghete, Tomocube Inc
4:45 pm short break
5:00 pm “Unveiling a pro-inflammatory role for mast cell-derived exoxomes”
Rosa Molfetta, Sapienza University of Rome
5:25 pm “Unconventional cell-to-cell regulation by exosomal miRNAs ”
Valentina Salvi, University of Brescia
5:50 pm -6:40 pm Selected talk/flash presentations:
(5:50 pm) Oral communication: “Identification of Chitinase 3-like 1 (CHI3L1) as a therapeutic target for pancreatic cancer present in large extracellular vesicles from human macrophages”
Cristina P.R. Xavier, University of Porto
(6:02 pm) Oral communication: “Anti-osteoblastogenic, proinflammatory and pro angiogenic effect of extracellular vesicles isolated from the human osteosarcoma cell line MNNG/HOS”
Argia Ucci, University of L’Aquila
(6:14 pm) Oral communication: “Metabolically labeled exosomes for biogenesis and functional studies”
Valeria Barreca, Istituto Superiore di Sanità, Rome
(6:25 pm) Flash presentation: “Involvement of microRNAs and extracellular vesicles in human papillomavirus induced
carcinogenesis”
Marco Iuliano, Sapienza University of Rome
(6:32 pm) Flash presentation: “Unraveling the role of tumorderived exosomal Alu RNAs in colorectal cancer”
Sara Magliacane Trotta, CNR, Napoli
6:40 pm “Tumor EV heterogeneity and functional consequences”
Lorena Martin-Jaular, Institut Curie, PARIS
7:20 pm End of session
CIRCULATING SIGNALS AND CANCER
Chairs: Massimo Donadelli, University of Verona and Chiara Riganti,
University of Turin
8:45 am “Proteomic insights into extracellular vesicle composition & cellular reprogramming”
David W. Greening, Baker Institute and La Trobe University, Australia
9:35 am “microRNA loading signatures”
Cecilia Battistelli, Sapienza University of Rome
10:15 am Technical Talk:“Rapid, accurate isolation and quantitation of nano biological particles”
Stephane Mazlan, Izon Science Ltd/Schaefer SEE
10:35 am Short Break
10:50 am “Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells”
Valentina Zappulli, University of Padua
11:15 am “Ewing Sarcoma derived exosomes mirror insulin-like growth factor 2 binding protein 3 (IMP3) cellular levels, modulating invasiveness of the receiving cells”
Veronica Giusti, Istituto Ortopedico Rizzoli, Bologna
11:35 am Technical Talk: ”Extracellular vesicles and Lipid nanoparticles:
Recent updates on matrix-free separation and characterization of novel drug carriers”
Lutz Ehrhardt, Beckman Coulter oteomic insights into extracellular vesicle composition & cellular reprogramming”
David W. Greening, Baker Institute and La Trobe University, Australia
11:55 am-1:00 pm Selected talks/short communications
(11:55 am) Oral communication: “BCLAF1 Functionalization in relapsed/refractory cancers”
Giulia Sgueglia, Campania University “Luigi Vanvitelli“
(12:07 pm) Oral communication: “Colorectal cancer-derived small extracellular vesicles induce epithelial to mesenchymal transition of normal hepatocytes: new insights on the hepatic pre-metastatic niche formation”
Marzia Pucci, University of Palermo
(12:20 pm) Oral communication: “Anaplastic thyroid cancer derived microvesicles promote epithelial to mesenchymal transition (EMT) in papillary cancer cells ”
Michele Aventaggiato, Sapienza University of Rome
(12:35 pm) Flash presentation: “Circulating extracellular vesicles in individuals at high-risk for lung cancer induce stromal cells pro-tumorigenic conversion by miR-126 and miR-320 transfer”
Francesca Pontis, IRCCS- Istituto Nazionale dei Tumori, Milan
(12:42 pm) Flash presentation: “The still undisclosed role of FZD10 delivering exosomes in cancer cell proliferation”
Federica Rizzi, University of Bari, CNR Bari
(12:50 pm) Flash presentation: “Dermal mesenchymal stem cell-derived exosomes drive melanoma progression towards quiescence ”
Deborah Magarre, Istituto Superiore di Sanità, Rome
1:00 pm end of session
CLINICAL POTENTIAL OF EXOSOMES AND VESICLES
Chairs: Katia Scotlandi, IOR Bologna, Michele Caraglia, Univ. of Campania “Luigi Vanvitelli”, Naples, Stefania Meschini, ISS Rome
2:00 pm “Anti-tumor activity of stem cell-derived extracellular vesicles”
Benedetta Bussolati, University of Turin
2:30 pm “The interplay between platelet-derived microvesicles and cancer cells”
Mauro Torti, University of Pavia
3:00 pm “Single Vesicle characterization using a new customizable array: access size, concentration, cargo and surface protein marker“
Roberto Santoliquido, ALFATEST
3:20 pm -4:05 pm Selected talks/short communications
(3:20 pm) Oral communication: “Tumor-targeting niosomes for phenformin brain delivery in medulloblastoma therapy”
Laura Di Magno, Sapienza University of Rome
(3:32 pm) Oral communication: “Nanotech revolution: miRNA delivery in glioblastoma as a new strategy to overcome temozolomide resistance by targeting O6-methylguanine methyl transferase (MGMT)”
Marianna Abate, Univ. of Campania “Luigi Vanvitelli”, Naples
(3:45 pm) Flash presentation: “Analysing leukaemia-derived EVs in the peripheral blood of Acute Myeloid Leukaemia patients: a reliable source of residual disease biomarkers?”
Hugo R. Caires, University of Porto
(3:52 pm) Flash presentation: “Next generation sequencing analysis reveals distinct transcripts and microRNAs in tumor multidrug resistant cells and extracellular vesicles when compared with their drug-sensitive counterparts”
Diana Sousa, University of Porto
(6:32 pm) Flash presentation: “NGB Exosomal Enrichment As A Novel Inter-Cellular Mechanism Of Neuroprotection”
Virginia Solar Fernandez , Roma Tre University
4:05 pm Short break
4:15 pm “Liposome-Protein Corona: New Opportunities for Targeted Drug Delivery and Early Disease Detection”
Giulio Caracciolo, Sapienza University of Rome
4:45 pm “Exosomes for delivery of therapeutic molecules”
Stefano Fais, Italian National Institute of Health, Rome
5:15 pm “Genotoxic stress affects the extracellular vesicle-mediated communication between Multiple Myeloma and Natural Killer cells”
Elisabetta Vulpis, Sapienza University of Rome
5:40 pm Short break
5:55 pm AWARD CEREMONY
6:00 pm: CLOSING LECTURE
“Exosome and exomere biomarkers for diagnosing cancer anddetermining prognosis”
David C. Lyden, Weill Cornell Medicine, New York, USA
6:40 pm CLOSING REMARKS
Enrico De Smaele, President, La Sapienza University of Rome
Aurelia Rughetti, La Sapienza University of Rome
Alessandra Zingoni, La Sapienza University of Rome
Marta Moretti, La Sapienza University of Rome
Annapaola Angrisani, La Sapienza University of Rome
Francesca Bufalieri, La Sapienza University of Rome
President
Michele Caraglia, Università Vanvitelli di Napoli, Naples (IT)
Vicepresident
Stefania Meschini, Istituto Superiore di Sanità, Rome (IT)
Board of Directors
Massimo Donadelli (Secretary), University of Verona, Verona (IT)
Francesca Zazzeroni (Treasurer), University of L’Aquila, L’Aquila, (IT)
Enrico De Smaele, La Sapienza University of Rome, Rome (IT)
Maria Teresa Di Martino, “Magna Graecia” University, Catanzaro, (IT)
Chiara Riganti, University of Turin, Turin, (IT)
Katia Scotlandi, (past President) IRCCS Istituto Ortopedico Rizzoli, Bologna, (IT)
| Registration Fees | Meeting fee (VAT included) |
|---|---|
| Regular Members | 120 euro |
| Undergraduate and PhD Students | 50 euro |
| Sapienza PhD Students from conventioned PhD programs | Free admission |
Registration to the meeting includes:
Registration without payment is not considered valid.
To partecipate to the meeting is required a valid AICC membership.
Membership request forms is HERE
To pay for the event dowload the registration form below.
2021 AICC membership is free of charge.
AICC will award at least three prizes for best oral presentation by authors younger than 35 years of age. Each award is worth 250 euros.
AICC will also awards at least six prizes for best poster (flash presentations) by authors younger than 35 years of age. Each award is worth 125 euros.
Under the patronage and sponsorship of:
Sapienza University of Rome (2021 meeting grant)
PhD program in Molecular Medicine
PhD program in Experimental Medicine
PhD program in Innovation in immuno-mediated and hematological disorders
| Abstract submission | Online registration |
|---|---|
| DEADLINE 25 May 2021 | DEADLINE 1 June 2021 |
Meeting secretariat
Enrico De Smaele
enrico.desmaele[at]uniroma1.it
Marta Moretti
marta.moretti[at]uniroma1.it
AICC Secretariat
Massimo Donadelli
massimo.donadelli[at]univr.it
Evelin Pellegrini
evelin.pellegrini[at]ior.it
Event technical support
Xenia Eventi xeniaeventi[at]gmail.com
President
Michele Caraglia, Università Vanvitelli di Napoli, Naples (IT)
Vicepresident
Stefania Meschini, Istituto Superiore di Sanità, Rome (IT)
Board of Directors
Massimo Donadelli (Secretary), University of Verona, Verona (IT)
Francesca Zazzeroni (Treasurer), University of L’Aquila, L’Aquila, (IT)
Enrico De Smaele, La Sapienza University of Rome, Rome (IT)
Maria Teresa Di Martino, “Magna Graecia” University, Catanzaro, (IT)
Chiara Riganti, University of Turin, Turin, (IT)
Katia Scotlandi, (past President) IRCCS Istituto Ortopedico Rizzoli, Bologna, (IT)
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