Dissecting metabolic circuitries in cancer cells and microenvironment:
how to learn from bad lessons to develop new therapeutic opportunities
The tumor cell and its microenvironment, including the stroma, the vascular component and the immune infiltrate, are linked by multiple cross talks that allow the adaptation of the cancer cells to unfavorable conditions, such as hypoxia, nutrient deprivation, cytotoxicity induced by radiotherapy and chemotherapy, host’s immune system recognition.
In this meeting, internationally recognized speakers will discuss the complexity of the metabolic changes that occur during tumor transformation, progression, and acquisition of resistance to therapy. The metabolic circuits established between the tumor cell and the microenvironment, leading to the selection of more aggressive and resistant clones, will be dissected and analyzed, with the final goal to identify new predictive and prognostic biomarkers for patient’s stratification and new therapeutic targets.
Recently, genomics, transcriptomics and proteomics have significantly improved the diagnostic accuracy and the therapeutic approach to the oncological patients, increasingly leading to personalized diagnoses and treatments. The metabolomics is an indispensable complement to the other “omic” techniques, if integrated with “omic” and single-cell imaging, flow-cytometry or molecular-biology-based assays, currently used at preclinical and clinical levels.
In the era of high-throughput techniques at the service of biomedical research and precision medicine, great importance will be given to the most innovative technologies that allow the metabolic mapping of each cancer and/or the generation of in vitro metabolic “avatars” of the individual patient, to make the stratification procedure and the efficacy of therapeutic treatment more and more accurate. The most relevant brands in the field will be present at the meeting, illustrating the latest innovations in a dedicated technical session.
We believe that the meeting will be highly attractive for a broad spectrum of scientists, working in basic and translational research, as well as in clinic units. Besides the presence of world-class speakers, the AICC meeting continues its long tradition of involving your researchers, dedicating slots for oral communications and posters. The best works presented by young scientists will be awarded by special prizes.
forward to seeing you all!
Prof. Michele Caraglia
AICC President
Prof. Chiara Riganti
AICC Board member
Meeting Organizer
12.30-14.00: Registration
14.00-14.20: Opening and Greetings
– Prof. Chiara Riganti (Università degli Studi di Torino, IT), meeting President
– Prof. Michele Caraglia (Università della Campania, “Luigi Vanvitelli”, IT), AICC President
Greeting from University of Torino Faculty members
– Prof. Federico Bussolino, Director of the Department of Oncology
– Prof. Fiorella Altruda, Director of the Interdepartmental Molecular Biotechnology
Center
– Prof. Paola Cappello, PhD program in Molecular Medicine
– Proff. Emilio Hirsch/Paolo E. Porporato, PhD program in Biomedical Sciences and
Oncology
Opening lecture
14.20-15.00: Alexander von Humboldt Professorship 2021 Awardee Lecture
Fumarate hydratase loss as a paradigm of oncometabolism
Christian Frezza, MRC Cancer Unit, University of Cambridge, UK & CECAD, University of Cologne, Germany
Session I – Emerging metabolic pathways in cancer initiation and progression
15.00-15.40 pm: Harnessing tumor metabolism to overcome immunosuppression Massimiliano Mazzone, VIB – KULeuven Center for Cancer Biology, Belgium
15.40-16.00: Hexosamine Pathway inhibition: one molecule hitting more than one target as promising cancer therapy
Ferdinando Chiaradonna, University of Milano Bicocca, Department of Biotechnology and Biosciences, Milano, Italy
16.00-16.30: coffee break and posters/virtual stands view
16.30-16.50: Targeting NAD(P) biosynthetic enzymes in cancer cells
Nadia Raffaelli, Polytechnic University of Marche, Ancona, Italy
16.50-17.10: Multistep reprogramming of myeloid cells in cancer
Antonio Sica, University of Eastern Piedmont “A. Avogadro”, Novara, Italy, and Humanitas Clinical and Research Center – IRCCS, Rozzano, Italy
17.10-17.30: Targeting NF-kB/CES1 axis to block colorectal cancer cell metabolic adaptation
Daria Capece, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy
17.30-17.40 pm: Agilent Cell Analysis. Emma Nora Di Capua, Agilent
17.40-17.50 pm: Metabolic determinants of therapy resistance in breast cancer. Andrea Morandi, University of Firenze, Italy
17.50-18.00 pm: Kynurenine importation by SLC7A11 propagates anti-ferroptotic signalling. Alessandra Fiore, Max Planck Institute, Martinsried, Germany
18.00-18.10 pm: Inhibition of heme export and/or heme synthesis potentiates metformin anti-proliferative effect on colorectal, pancreatic and lung cancer cell lines. Anna LuciaAllocco, University of Torino, Italy
18.10: closing remarks of day I
18.15-19.00: AICC Steering Board (members only)
Free evening & guided tour of Torino on demand
8.00-9.00: Registration
Session II – Metabolic rewiring in tumor progression and response to therapy
9.00-9.40: Novel connections between autophagy pathways and the metabolic control of gene expression in cancer and inflammation
Patrizia Agostinis, Cell Death Research & Therapy lab, Department of Cellular and Molecular Medicine & VIB Center for Cancer Biology, KU Leuven, Leuven, Belgium
9.40-10.00: Survival pathways triggered by respiratory Complex I deficiency in solid cancers
Anna Maria Porcelli, Department of Pharmacy and Biotechnology, University of Bologna, Italy
10.00-10.20: P53 modifies the outcome of inducing metabolic collapse as an anticancer strategy
Giuseppe Gasparre, Medical Genetics Unit, Department of Medical and Surgical Sciences (DIMEC) and Center for Applied Biomedical Research (CRBA), University of Bologna, Italy
10.20-10.40: Regulation of protein synthesis and respiration by a common molecular chaperone to develop novel therapeutic approaches in cancer cells
Franca Esposito, Department of Molecular Medicine and Medical Biotechnologies, Università di Napoli Federico II, Napoli, Italy
10.40-11.00: Cancer metastasis prevention with selective mtROS inhibitors
Pierre Sonveaux, Pole of Pharmacology & Therapeutics, IREC Institute, catholic University of Louvain (UCLouvain), Belgium
11.00-11.30: coffee break and posters/virtual stands view
Session III – Dealing with complexity: metabolic plasticity and heterogeneity in cancer progression (Chairs: Francesca Zazzeroni,Joanna Kopecka)
11.20-11.40 am: Metabolic heterogeneity as a driver of stem cell fate and tumorigenesis. Carlos Sebastian, Department of Cell Biology, Physiology and Immunology, University of Barcelona,
11.40-12.00 am: The chromatin role of MTHFD2 in cancer. Sara Sdelci, Centre for Genomic Regulation, Barcelona, Spain
12.00 -12.10 am: Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance. Sirio Dupont, University of Padova, Italy
12.10-12.20 am: MiR423-5p/Malat-1 loop asa new tool for therapeutic intervention in Hepatocarcinoma. Marco Bocchetti, University of Campania “Luigi Vanvitelli”, Napoli, Italy
12.20-12.30 am: Video Killed the Imaging Star. Francesco Girardi, Media System Lab
12.30-12.40 am: Microtech: the logical choice. Davide Liccardo, Microtech
12.40-12.50 am: Altered iron metabolism promotes cancer-induced muscle wasting. Myriam Hsu, University of Torino, Italy
12.50 am-13.00 : SIRT3 and metabolic reprogramming mediate the antiproliferativeeffects of whey in human colon cancer cells. Nunzia D’Onofrio, University of Campania “Luigi Vanvitelli”, Napoli, Italy
13.10-14.00: lunch and poster view
Session IV – Disrupting the bad liaisons between tumor and its microenvironment (I)
14.00-14.20 pm: Rewiring of acetyl-CoA metabolism supports pancreatic carcinogenesis. Alessandro Carrer, Veneto Institute of Molecular Medicine (VIMM) and Department of Biology, University of Padova, Italy
14.20-14.40 pm: A lysosomal lipid switch sensitizes to nutrient deprivation and mTOR targeting in pancreatic cancers. Emilio Hirsch, Molecular Biotechnology Center, University of Torino, Italy
14.40-15.00: Macrophage Immunometabolism: where are we (going)
Jan Van den Bossche, Department of Molecular Cell Biology and Immunology, Amsterdam UMC, Vrije Universiteit Amsterdam
15.00-15.10: Complex biology, tailored solutions. Guido Cimoli, LSA Automated
Solutions Europe/Tecan
15.10-15.20: IVTech: the next generation of in-vitro models. Tommaso Sbrana, IVTech
15.20-15.30 Iron-induced oxidative stress promotes PD-L1 transcription through the activation of c-Myc in Non-Small Cell Lung Cancer (NSCLC) cells. Anna Martina Battaglia, University of Catanzaro “Magna Graecia”, Catanzaro, Italy
15.30-15.40: Osteoblast-derived extracellular vesicles influence MNNG/HOS osteosarcoma cells’ metabolic activity and redox balance. Marco Ponzetti, University of L’Aquila, Italy
3.40-3.50: Primary bone marrow-derived mesenchymal stem cells secrete citrate and take up glutamate under physiological culture conditions. Giuseppe Taurino, University of Parma, Italy
15.50-16.10: coffee break and posters/virtual stands view
Session V – Disrupting the bad liaisons between tumor and its microenvironment (II)
16.10-16.50: Lactate-driven metabolic and epigenetic prostate tumor-stroma crosstalk
Paola Chiarugi, Department of Experimental and Clinical Biomedical Sciences, School of Medicine, University of Firenze, Italy
16.50-17.10: At the crossroads of tumor microenvironment and metabolism: role of acidosis in tumor evolution
Cyril Corbet, Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), UCLouvain, Brussels, Belgium
17.10-17.30: Targeting lactate transport as a therapeutic approach in cancer
Fatima Baltazar, Life and Health Sciences Research Institute (ICVS), University of Minho, Portugal
17.30: closing remarks of day II
17.30-18.30: AICC general assembly (AICC members only)
20.00: social dinner
Session VI – From the complexity of cancer cell metabolism toward a new therapeutic era
9.00-9.40: Microenvironment and mechanosignalling in cancer: emerging roles of mutant p53 and Pin1
Giannino Del Sal, Department of Life Sciences, University of Trieste, ICGEB-International Centre for Genetic Engineering and Biotechnology-Trieste, and IFOM-Firc Institute of Molecular Oncology- Milano, Italy
9.40-10.00: Repurposing metabolic drugs revealed lipid anabolism as a metabolic vulnerability to kill Triple-Negative Breast Cancer Stem-Like Cells and reduce metastases
Luca Cardone, Institute of Biochemistry and Cell Biology (IBBC)-National Research Council (CNR), Roma, and Tumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, Roma, Italy
10.00-10.20: A sound waves-based platform for 3D cancer model development
Tiziano Serra, AO Research Institute, Davos, Switzerland
10.20-10.40: Metabolic insights from cell culture to animal models
Saverio Tardito, Oncometabolism Lab – Cancer Research UK Beatson Institute, Glasgow, United Kingdom
10.40-10.50: Tumor microenvironment and-omics: the role of gentle cell sorting. Dario Leone, MM BioTech/Miltenyi
11.00-11.10 am: 3D, Label-Free, Live Cell Imaging for Cell Morphology. Daniel Ghet,Tomocube
11.10-11.30: coffee break and posters/virtual stands view
Closing lecture (Chairs: Katia Scotlandi, Andrea Graziani)
11.30-12.10: Translating current metabolic knowledge into future cancer therapy
Eyal Gottlieb, Laura and Isaac Perlmutter Chair of Cancer Research, Ruth and Bruce Rappaport Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel
12.10-12.30: Awards ceremony and Closing Remarks
Patrizia Agostinis, UCL Louvain, Louvain, Belgium
Fatima Baltazar, University do Minho, Porto, Portugal
Luca Cardone, CNR/IRCCS Istituto Regina Elena, Roma
Daria Capece, Universotà de L’Aquila
Alessandro Carrer, Veneto Institute of Molecular Medicine (VIMM), Padova
Ferdinando Chiaradonna, Università degli Studi di Milano Bicocca, Milano
Paola Chiarugi, Università degli Studi di Firenze
Cyril Corbet, UCL Brussels, Belgium
Giannino Del Sal, IFO/Università degli Studi di Trieste
Franca Esposito, Università Federico II, Napoli
Christian Frezza, MRC/University of Cambridge, UK
Giuseppe Gasparre, Università degli Studi di Bologna
Eyal Gottlieb, Technion University, Haifa, Israel
Emilio Hirsch, Università degli Studi di Torino
Massimiliano Mazzone, UCL Louvain, Louvain, Belgium, and Università degli Studi di Torino
Anna Maria Porcelli, Università degli Studi di Bologna
Claudia Piccoli, Università degli Studi di Foggia
Nadia Raffaelli, Università Politecnica delle Marche
Sara Sdelci, Centre for Genomic Regulation, Barcelona, Spain
Carlos Sebastian, University of Barcelona, Spain
Tiziano Serra, AO Foundation, Davos, Switzerland
Antonio Sica, Fondazione Humanitas, Università degli Studi del Piemonte Orientale
Pierre Sonveaux, UCL Louvain, Louvain, Belgium
Saverio Tardito, Beatson Research Institute, Glasgow, UK
| Registration Fees | Meeting fee (VAT included) |
|---|---|
| On-site attendance (maximum 100 participants) | 200 euro |
| On-line attendance (no limit of participants) | 150 euro |
| PhD students, students of medical specialization schools, undergraduate students (both on-site/on-line) * | 75 euro |
| PhD students of the School of Health and Life Sciences, students of School of Medicine, University of Torino (both on-site/on-line) ** | Free admittance |
* Please provide a certificate of your status of student along with the payment receipt to: aicc.meeting[at]gmail.com
** To register: do not use the link to the Google form, but send the “Registration form for UNITO students” (from: https://www.aicc.website/), with a certificate of your enrollment in the PhD School of Health and Life Sciences , or School of Medicine, University of Torino, to: aicc.meeting[at]gmail.com.
The first 20 registered students from University of Torino have the possibility to attend on-site; from the 21st registration, online attendance is possible (with no limit of participants).
Please notice that in case you have chosen to attend onsite and you change this option/would not be able to attend, you can attend online, but AICC cannot pay back the difference between the onsite and the online fee.
Registration to the meeting includes:
– Admission to all meeting sessions and meeting online material
– Abstract book file (PDF)
– Attendance certificate
– Conference kit
– Coffee break, light lunch
Registration without payment is not considered valid.
PAYMENT
Bank transfer to:
Associazione Italiana di Colture Cellulari
BPER BANCA S.P.A.
IT97B0538703612000003002045
L’Aquila, agenzia 10, Via Campo di Pile, 67100 L’Aquila (AQ)
Reason for payment (causale): please, indicate your surname, name and title of the event.
Opening: 1st October 2021 – Deadline: 10st November 2021
For all participants except UNITO students, please use this link:
Please note that this is a provisional registration; the registration will be confirmed after completing the payment and sending the receipt of the payment to: aicc.meeting[at]gmail.com
To participate to the meeting is required a valid AICC membership. Membership is free for the year 2021.
Participants will be informed of the selection by 15th November, 2021.
The deadline to submit poster+ flash presentation is 18th November
2021.
For UNITO students:
do not use the above link, but send the “Registration form for UNITO students”, along with a certificate of your enrollment in the PhD School of Health and Life Sciences or School of Medicine, to: aicc.meeting[at]gmail.com
REGISTRATION FORM for UNITO STUDENTS
| Registration and asbtract submission | Registration and asbtract submission |
|---|---|
| OPENING 1 october 2021 | DEADLINE 10 november 2021 |
President
Michele Caraglia, Università Vanvitelli di Napoli, Naples (IT)
Vicepresident
Stefania Meschini, Istituto Superiore di Sanità, Rome (IT)
Board of Directors
Massimo Donadelli (Secretary), University of Verona, Verona (IT)
Francesca Zazzeroni (Treasurer), University of L’Aquila, L’Aquila, (IT)
Enrico De Smaele, La Sapienza University of Rome, Rome (IT)
Maria Teresa Di Martino, “Magna Graecia” University, Catanzaro, (IT)
Chiara Riganti, University of Turin, Turin, (IT)
Katia Scotlandi, (past President) IRCCS Istituto Ortopedico Rizzoli, Bologna, (IT)
Meeting secretariat
Enrico De Smaele
enrico.desmaele[at]uniroma1.it
Evelin Pellegrini
evelin.pellegrini[at]ior.it
Event technical support
Xenia Eventi xeniaeventi[at]gmail.com
On-site Secretariat
Joanna Kopecka
joanna.kopecka[at]unito.it
Iris Chiara Salaroglio
irischiara.salaroglio[at]unito.it
Chiara Riganti
Federico Bussolino
Paola Cappello
Andrea Graziani
Joanna Kopecka
Letizia Lanzetti
Miriam Martini
Franco Novelli
Evelin Pellegrini
Fabio Penna
Paolo E. Porporato
Luca Primo
Guido Serini
University of Torino
School of Medicine, University of Torino
MD/PhD Program of the School of Medicine
PhD School in Health and Life Sciences, University of Torino
PhD program in Molecular Medicine
PhD program in Biomedical Sciences and Oncology
PhD program in Experimental Medicine and Therapy
PhD program in Medical Physiopathology
PhD program in Complex Systems for Quantitative Biomedicines
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